What is PGD?
PGD is a technique that enables couples with a particular inherited condition in their family to avoid passing it on to their children. The process helps potential parents prevent the birth of a child with a serious genetic condition. PGD is used when one or both parents have a known genetic abnormality and diagnostic testing is performed on an embryo to determine if it has also inherited the abnormality.
Who might use PGD?
Couples who request PGD are at risk of passing on a serious genetic condition to their children. Parents may have these conditions themselves or be carriers of the conditions. They may already have a child affected with the genetic condition or they may have even experienced the loss of a child or pregnancy affected with the condition.
Primary candidates for PGD include:
• Carriers of a serious autosomal recessive condition: For carriers of an autosomal recessive condition, there is a 1 in 4 risk of each pregnancy delivering an affected child.
• Carriers of a serious autosomal dominant condition: For carriers of an autosomal dominant condition, there is a 1 in 2 risk of each pregnancy delivering an affected child.
• Couples with chromosome disorders.
• Couples with a family history of serious sex-linked disorders: Couples with a family history of a sex-linked disorder have a 1 in 4 risk of each pregnancy delivering an affected child (half of all male children).
Therefore, PGD may be recommended if:
• you or your partner has a family history of a serious genetic condition and/or
• you and your partner already have a child with a serious genetic condition and/or
• You and your partner have had a number of pregnancy terminations because your baby had a serious genetic condition.
The procedure for PGD is usually as follows:
Step 1: You undergo normal in vitro fertilisation (IVF) treatment to collect and fertilise your eggs.
Step 2: The embryo is grown in the laboratory for two to three days until the cells have divided and the embryo consists of around eight cells.
Step 3: Embryologist removed one cell from the embryo.
Step 4: The cells are tested to see if the embryo from which they were removed contains the gene that causes the genetic condition in the family.
Step 5: The embryo unaffected by the condition is transferred to the womb to allow it to develop.
Thu, 01/07/2016 - 11:27 | Category: PGD