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Preimplantation Genetic Diagnosis |
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Embryos obtained after in vitro fertilization can be examined genetically and healthy embryos can be differentiated from unhealthy embryos and this method is known as preimplantation genetic diagnosis (PGD). This method results in the transfer of screened embryos to the mother. Today man hereditary diseases can be diagnosed in the embryo using PGD.

PGD renders prenatal diagnosis of chromosomal abnormalities (monosomi or trisomi) and single gene disorders (thalassemia, cystic fibrosis, hemophilia, muscular dystrophy, sickle cell anemia, neurofibromatosis, Fanconi anemia etc) possible. If an X-linked disease is suspected, determination of gender enables the transfer of female embryos that are devoid of the disease.
Advantages of PGD - selection of healthy embryos in women at advanced ages - increase in implantation rates in women with recurrent implantation failure - decrease in the number of higher order pregnancies - decrease in the number of therapeutic abortions - increase in clinical pregnancy rates
To who and how is PGD performed? - Your doctor and geneticist decide together whether PGD is required. Afterwards, patient consent is obtained. - Patient is prepared for IVF - Appropriate timing of egg collection is decided by the physician - Fertilization is achieved via microinjection - Genetic screening of biopsied cells is performed - Screened healthy embryos are transferred |
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